Nature communications – biostate.AI

March 8, 2024

Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo

CA1 pyramidal neuron dendrites show layer-specific mitochondrial morphology, from highly fused in apical tufts to fragmented in basal compartments.

October 11, 2022

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Whole genome sequence analysis of blood lipid levels in> 66,000 individuals

One major challenge in the design of multiplexed PCR primer sets is the large number of primer dimer species that grows quadratically with the number of primers to be designed.

April 11, 2022

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Designing highly multiplex PCR primer sets with simulated annealing design using dimer likelihood estimation (SADDLE)

SADDLE uses simulated annealing to optimize 96-plex PCR primers, reducing primer dimer formation from 90.7% to 4.9%.

April 4, 2022

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Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling

QASeq scales absolute DNA quantitation to 200+ modules, surpassing ddPCR.

October 21, 2021

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Calibration-free NGS quantitation of mutations below 0.01% VAF

Quantitation of rare somatic mutations is essential for basic research and translational clinical applications including minimal residual disease (MRD) detection.

July 19, 2021

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A deep learning model for predicting next-generation sequencing depth from DNA sequence

Targeted high-throughput DNA sequencing is a primary approach for genomics and molecular diagnostics, and more recently as a readout for DNA information storage.

October 6, 2020

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Metastable hybridization-based DNA information storage to allow rapid and permanent erasure

The potential of DNA as an information storage medium is rapidly growing due to advances in DNA synthesis and sequencing.

June 25, 2018

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Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Purification of oligonucleotides has traditionally relied on mobility-based separation methods.

January 19, 2016

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Native characterization of nucleic acid motif thermodynamics via non-covalent catalysis

Method measures ΔG° of DNA motifs with 6- to 14-fold lower s.e. than prior methods across 10 to 45 °C.

June 12, 2013

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Integrating DNA strand-displacement circuitry with DNA tile self-assembly

DNA tile self-assembly and DNA strand-displacement circuits are integrated to provide programmable control of triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm.

Project Category: Nature communications