Project Category: Nature Chemistry

January 1, 2018

Predicting DNA hybridization kinetics from sequence

Hybridization is a key process in biology and biotechnology, but there is no predictive model for accurately determining hybridization rate constants from sequence information.

May 25, 2015

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Simulation-guided DNA probe design for consistently ultraspecific hybridization

Hybridization of complementary sequences is one of the central tenets of nucleic acid chemistry; however, the unintended binding of closely related sequences limits the accuracy of hybridization-based approaches to analysing nucleic acids.

July 28, 2013

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Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA

Small variations in nucleic acid sequences can have far-reaching phenotypic consequences.

January 22, 2012

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Optimizing the specificity of nucleic acid hybridization

The specific hybridization of complementary sequences is an essential property of nucleic acids, enabling diverse biological and biotechnological reactions and functions.

January 24, 2011

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Dynamic DNA nanotechnology using strand-displacement reactions

DNA nanotechnology uses strand-displacement reactions for dynamic devices.