Biostate’s whole exome sequencing platform delivers high coverage uniformity, minimal zero-coverage regions, and exceptional reproducibility, enabling accurate detection of disease-related genetic variants across all sample types.
While most WES providers guarantee raw sequencing output, true value depends on data quality.
Biostate’s optimized workflow achieves rapid coverage convergence, with >95% of bases covered with >30X (mean = 100X), significantly outperforming leading competitors.
Biostate maintains a superior on-target rate of ~96%, with significantly reduced duplication and improved hybridization efficiency.
The Fold 80 Base Penalty of 1.52 indicates exceptional uniformity, enabling 15–20% reduction in sequencing costs while maintaining diagnostic quality.
Biostate minimizes zero-coverage regions to just 1.2%, delivering reliable coverage even across challenging loci.
With this high-quality library performance, the WES platform demonstrates robust variant reproducibility using genomic DNA inputs as low as 10 ng, achieving 99% concordance with variant calls obtained from 100 ng input.
Biostate’s optimized workflow demonstrates exceptional performance across key metrics, overcoming the coverage uniformity and duplication challenges that undermine variant detection in standard WES workflows.
Biostate achieves ~140X mean target coverage at 40M reads from FFPE samples, despite severe degradation.
This performance supports reliable somatic variant detection even from challenging clinical materials.
A single half-circle dried blood spot yields ~140X mean target coverage, demonstrating consistent performance even with limited DNA input.
Benchmark genomic DNA processed through the same workflow also reaches ~140X coverage, confirming strong chemistry performance across both high-quality and compromised input types.
MARE is a targeted enrichment technology engineered to rescue difficult genomic regions that standard WES consistently misses—especially exons with extreme GC content.
- ≈260% median target coverage, vs. ~30% (Competitor A) and <10% (Competitor B)
- Maintains >150% normalized coverage on challenging exons such as RALGAPA1 exon 25
- Fully customizable panels for clinically relevant or high-value gene sets
Speak with our experts to tailor solutions to your specific research needs.
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